Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles |
| |
Authors: | Min Cao Ying Mao Jiancheng Huang Yudao Ma Lei Liu |
| |
Institution: | 1. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;2. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China |
| |
Abstract: | Current studies on cross-dehydrogenative coupling of benzylic ethers for new C–C bond construction predominantly focus on primary ether moieties. Oxidative cross-coupling of secondary benzylic ethers remains elusive. Herein, we describe the first cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles for tertiary ether construction. A broad range of α-aryl substituted isochromans react with a variety of electronically varied indoles and pyrroles smoothly under mild metal-free conditions in high efficiency. In addition, the catalytic asymmetric variant was preliminarily explored, and corresponding tertiary ether was obtained in 69% ee. |
| |
Keywords: | Cross-dehydrogenative coupling Secondary benzylic ether Indole Quaternary center |
本文献已被 ScienceDirect 等数据库收录! |