Copper-catalyzed four-component synthesis of imidazo[1,2-a]pyridines via sequential reductive amination,condensation, and cyclization |
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Authors: | Emad Allahabadi Sina Ebrahimi Mehdi Soheilizad Mehdi Khoshneviszadeh Mohammad Mahdavi |
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Affiliation: | 1. Drug Design and Development Research Center, Tehran University of Medical Science, Tehran 14176, Iran;2. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran;3. Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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Abstract: | A novel and efficient four-component approach for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridines is described. The copper-catalyzed reductive amination of 2-bromopyridine by sodium azide followed by sequential condensation and cyclization with aldehydes and isocyanides afforded the corresponding imidazo[1,2-a]pyridines in good yields. |
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Keywords: | Copper-catalyzed Reductive amination 2-Bromopyridine Aldehyde Isocyanide Sodium azide |
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