Base-promoted three-component cascade approach to unsymmetrical bis(indolyl)methanes |
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Authors: | Mohit L Deb Bhaskar Deka Prakash J Saikia Pranjal K Baruah |
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Institution: | 1. Department of Applied Sciences, GUIST, Gauhati University, Guwahati 781014, Assam, India;2. Analytical Chemistry Division, CSIR-NEIST, Jorhat 785006, India |
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Abstract: | Here we report a base-catalyzed reaction of two different indoles with aldehydes under heating to produce unsymmetrical bis(indolyl)methanes (BIMs), in which one of the indole ring must be N-substituted. Mixture of EtOH-H2O is used as solvent. The reaction did not give symmetrical BIMs of N-substituted indoles or N–H indoles. However, traces of latter were formed in few cases, especially when electron-rich aldehydes were used. Diversely substituted indoles and aldehydes were used for the reaction. The reaction proceeds via 3-indolylalcohol, which we confirmed through isolation. The method also gives good yield on multigram scale reaction. |
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Keywords: | Multi-component Cascade approach Unsymmetrical bis(indolyl)methanes Base catalyzed |
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