Ir(I)-catalyzed enantioselective hydrogenolysis of 3-aryl-3-hydroxyisoindolin-1-ones |
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| Authors: | Chen Ge Ren-Xiao Liang Ren-Rong Liu Bin Xiang Yi-Xia Jia |
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| Institution: | College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China |
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| Abstract: | An enantioselective hydrogenolysis of 3-aryl-3-hydroxyisoindolin-1-ones under H2 has been developed by using Ir(I)/(R)-MeO-Biphep complex as a catalyst. Cyclic diaryl methylamides were obtained in moderate to excellent yields and up to 92% ee. |
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| Keywords: | Hemiaminal Iridium Asymmetric hydrogenolysis |
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