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Regioselective dehydroxytrifluoromethylthiolation of allylic and propargylic alcohols with AgSCF3 |
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| Authors: | Yin-Li Liu Xiu-Hua Xu Feng-Ling Qing |
| Institution: | 1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Science, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China;2. Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China |
| Abstract: | The reaction of easily available Morita–Baylis–Hillman (MBH) alcohols with AgSCF3 in the presence of n-Bu4NI and KI affords primary allylic SCF3 products in high yields and excellent regioselectivities. This regioselective dehydroxytrifluoromethylthiolation protocol could also be extended to propargylic alcohols for the preparation of the primary propargylic SCF3 products. |
| Keywords: | Trifluoromethylthiolation Allylic alcohol Propargylic alcohol Regioselective |
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