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Catalytic asymmetric synthesis of Leukotriene B4 |
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| Authors: | Pengfei Yang Jiangchun Zhong Kaijie Ji Jingwei Yin Shuoning Li Siyuan Wei Yun Zhou Lifeng Wang Min Wang Qinghua Bian |
| Institution: | Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193, PR China |
| Abstract: | Leukotriene B4 1 was prepared from two chiral synthons 8 and 14. The chiral secondary alcohols of 8 and 14 were constructed by BINOL/Ti(OiPr)4 catalyzed enantioselective alkynylzinc addition to aldehydes. |
| Keywords: | Corresponding author Tel : +86 010 62731356 fax: +86 010 62820325 |
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