Reprint of: Acid-mediated four-component tandem cyclization: Access to multifused 1,3-benzoxazine frameworks |
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| Authors: | Jungang Wang Rongrong Zhou Shiyi Zhuang Anxin Wu |
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| Affiliation: | 1. School of Chemical Engineering, Guizhou Minzu University, Guiyang, 550025, China;2. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, China |
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| Abstract: | An acid-mediated multicomponent reaction has been developed for the direct synthesis of multifused 1,3-benzoxazine derivatives from simple and readily available arylglyoxal monohydrates and 2-aminobenzyl alcohols under mild conditions. This novel protocol is proposed to proceed through intramolecular poly-heterocyclizations, thus leading to the formation of three new rings and six new chemical bonds, including four C | |
| Keywords: | Multicomponent reaction Benzoxazine Multifused heterocycles Acid-mediated |
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