Enhancement of saccharothriolide production and discovery of a new metabolite,saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis |
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| Authors: | Yulu Jiang Shan Lu Go Hirai Taira Kato Hiroyasu Onaka Hideaki Kakeya |
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| Affiliation: | 1. Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan;2. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan;3. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;4. Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;5. Research & Development Division, MicroBioPharm Japan Co Ltd., Aichi 452-0915, Japan;6. Present address: Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Okinawa 903-0213, Japan |
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| Abstract: | A combined-culture method was applied to saccharothriolide-producing strain Saccharothrix sp. A1506 with the mycolic acid-containing bacterium (MACB) Tsukamurella pulmonis TP-B0596. The combined-culture not only enhanced saccharothriolide production, but also produced saccharothriolide C2, a new C-2 epimer of saccharothriolide C, thereby indicating its potential for increasing the chemical diversity of microbial metabolites. |
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| Keywords: | Combined-culture Saccharothriolides Corresponding author. |
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