CN bond formation and cyclization: A straightforward and metal-free synthesis of N-1-alkyl-2-unsubstituted benzimidazoles |
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| Authors: | Xuejing Liu Han Cao Fusheng Bie Peng Yan Ying Han |
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| Affiliation: | Zaozhuang University and Lunan Institute of Coal Chemical-engineering Technology Research, Zaozhuang 277160, China |
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| Abstract: | A straightforward and metal-free synthesis of N-1-alkyl-2-unsubstituted benzimidazoles from the corresponding o-fluoro aryl formamidines and primary amines using microwave irradiation is described. The displacement of -F by the primary amine and cyclization to form the corresponding benzimidazoles took place in one pot. |
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| Keywords: | Benzimidazoles Formamidine Cyclization Microwave |
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