Pd(II) complexes of monodentate deoxycholic acid derived binaphthyl diamido phosphites as chiral catalysts in the asymmetric Suzuki-Miyaura cross-coupling |
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| Authors: | Grazia Iannucci Vincenzo Passarelli Alessandro Passera Anna Iuliano |
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| Institution: | 1. Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Moruzzi 13, 56124 Pisa, Italy;2. Centro Universitario de la Defensa, Ctra. Huesca s/n, 50090 Zaragoza, Spain;3. Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC—Universidad de Zaragoza, Departamento de Química Inorgánica, Pedro Cerbuna 12, 50009 Zaragoza, Spain;4. Classe di Scienze Matematiche e Naturali, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy |
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| Abstract: | Chiral binaphthyl diamidophosphites derived from deoxycholic acid were synthesized and used as ligands for the preparation of mononuclear Pd(II) complexes, which were employed as catalysts in the asymmetric Suzuki-Miyaura cross-coupling of arylboronic acids with aryl bromides. Among the different reaction parameters, the substrate concentration emerged as being crucial for the outcome of the reaction: the reaction was faster in a concentrated reaction mixture, and could be performed at 0 °C, where the reaction promoted by the Pd-complexes was more enantioselective affording cross-coupling products with ee up to 70%. |
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| Keywords: | Corresponding author |
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