Integrated fluidic systems on a nanometer scale and the study on behavior of liquids in small confinement |
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| Authors: | Akihide Hibara Takehiko Tsukahara Takehiko Kitamori |
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| Affiliation: | 1. Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan;2. Micro Chemistry Group, Kanagawa Academy of Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki-shi, Kanagawa 213-0012, Japan;3. Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, 2-12-1-N1-32 O-Okayama, Meguro-ku, Tokyo 152-8550, Japan;4. Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan |
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| Abstract: | Nanofluidic systems and the studies on the behavior of liquids confined in nanometer-sized space are reviewed. Miniaturized chemical systems having nanometer-sized structures are fabricated by using advanced nanofabrication techniques. The size-confinement effect is expected to be applied in well-controlled chemical and biochemical analysis. While electroosmosis and electrokinetic migration in small-sized channels have been investigated extensively, there have been few reports on pressure-driven flow systems having nanometer-sized structures, which are widely used in laboratory-scale and micrometer-sized systems. In this review, fundamental technologies that can be used in integrated chemical analysis systems having nanometer-sized structures are introduced. In addition to the technological investigations, important topics in the fundamental research on the properties of liquids confined in nanometer-sized space are also presented. |
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| Keywords: | Nanofluidics Nanometer-sized channel Microchip Pressure-driven flow Capillary introduction |
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