Glass microchip with three-dimensional microchannel network for 2 x 2 parallel synthesis |
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Authors: | Kikutani Yoshikuni Horiuchi Takayuki Uchiyama Kenji Hisamoto Hideaki Tokeshi Manabu Kitamori Takehiko |
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Affiliation: | Integrated Chemistry Project, Kanagawa Academy of Science and Technology (KAST), Kanagawa, Japan. |
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Abstract: | An integrated multireactor system for 2 x 2 parallel organic synthesis has been developed on a single glass microchip. Three-dimensional channel circuits in the chip were fabricated by laminating three glass plate layers. The fabrication method is a straightforward extension of the conventional one, and topological equivalence for any three-dimensional circuits can be constructed easily with it. 2 x 2 phase-transfer amide formation reactions, which constitute a simple model for combinatorial synthesis, were successfully carried out on the microchip, and the integrity of the three-dimensional circuits was confirmed. Combinatorial chemistry with multi-microreactors, in conjunction with a high-throughput screening method based on micro-TAS technologies, is expected to provide an efficient tool for drug discovery. |
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