| 泌尿系统尿酸结石研究中的化学基础 |
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| 引用本文： | 欧阳健明,郑辉. 泌尿系统尿酸结石研究中的化学基础[J]. 化学通报, 2006, 69(5): 382-387 |
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| 作者姓名： | 欧阳健明 郑辉 |
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| 作者单位： | 暨南大学生物矿化与结石病防治研究所,广州,510632;中国科学院化学研究所,北京,100080;暨南大学生物矿化与结石病防治研究所,广州,510632 |
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| 基金项目： | 中国科学院资助项目;广东省科技攻关项目;中国科学院有机固体实验室基金 |
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| 摘 要： | 尿酸结石是指尿酸及其盐在泌尿系统的异常矿化和积聚。本文从尿酸结石研究中涉及的化学问题入手,讨论了pH、过饱和度、尿大分子抑制剂和基因突变等方面对尿酸结石形成的分子机理,从抑制尿酸结石成核、生长和聚集的角度,讨论了尿酸结石的化学模型和动物实验模型。
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| 关 键 词： | 尿酸 泌尿系结石 生物矿化 |
| 收稿时间： | 2005-07-11 |
| 修稿时间： | 2005-07-112005-12-17 |
Chemical Basis in Investigation of Uric Acid Stones in Urinary System |
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| Ouyang Jianming,Zheng Hui. Chemical Basis in Investigation of Uric Acid Stones in Urinary System[J]. Chemistry, 2006, 69(5): 382-387 |
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| Authors: | Ouyang Jianming Zheng Hui |
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| Affiliation: | 1.Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632; 2 Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 |
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| Abstract: | Uric acid stone is referred as the abnormal biomineralization and aggregation of uric acid and urates. In this paper, the chemical problems and molecular mechanisms in the formation of uric acid stones were discussed from the points of pH, supersaturation, urinary macromolecule inhibitors and gene mutation etc. The chemical models and animal experiment models of uric acid stones were also discussed from the points of nucleation, growth and aggregation of uric acid crystals. |
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| Keywords: | Uric acid Urinary stone Biomineralization |
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