Spectrofluorimetric determination of benzodiazepinooxazoles |
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Authors: | A Melón R M Alonso and R M Jiménez |
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Institution: | (1) Departamento de Química Analítica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48080 Bilbao, Spain |
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Abstract: | Summary A study of fluorescence properties of Cloxazolam and Oxazolam has been carried out. pKa-values were calculated and a spectrofluorimetric method was developed in acidic hydroalcoholic medium for the determination of the drugs. The fluorescence intensity was linear with the concentration up to at least 6.00×10–6 mol/l for Cloxazolam and 5.17×10–6 mol/l for Oxazolam. Detection limits obtained were 2.91×10–8 mol/l and 4.56×10–8 mol/l for Cloxazolam and Oxazolam, respectively. Spectrofluorimetric methods were applied to the determination of both drugs in pharmaceuticals and errors lower than 2.5% were obtained. Spectrophotometric determination methods were also developed. |
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