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Highly enantioselective synthesis of organic compound using right- and left-handed helical silica |
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| Authors: | Itaru SatoKousuke Kadowaki Hiroki UrabeJong Hwa Jung Yoshiyuki OnoSeiji Shinkai Kenso Soai |
| Affiliation: | a Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan b Chemotransfiguration Project, Japan Science and Technology Corporation (JST), 2432 Aikawa, Kurume, Fukuoka 839-0861, Japan |
| Abstract: | Highly enantiomerically enriched (up to 96-97% ee) 5-pyrimidyl alkanol was obtained by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in the presence of the artificially designed chiral inorganic material, right- and left-handed helical silica. |
| Keywords: | asymmetric induction asymmetric synthesis addition reactions asymmetric autocatalysis silica |
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