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Rapid synthesis of C-labeled FK506 for positron emission tomography |
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| Authors: | Yoshihiro Murakami Akio KurodaKazuhiko Osoda Shintaro Nishimura |
| Affiliation: | a Advanced Technology Platform Research Laboratory, Fujisawa Pharmaceutical Co. Ltd, 5-2-3, Tokodai, Tsukuba, Ibaraki 300-2698, Japan b The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama-cho, Hakui, Ishikawa 925-0613, Japan c Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 5-2-3, Tokodai, Tsukuba, Ibaraki 300-2698, Japan |
| Abstract: | The present study describes a rapid synthesis method for labeled [11C]FK506 for positron emission tomography (PET). A one-pot reaction from [11C]CH3I, involving a Wittig reaction as the key carboncarbon bond formation was developed. The chemical process was accomplished using a designed, fully automated synthetic apparatus, and an injectable solution of [11C]FK506 was obtained in only 34 min from [11C]CH3I. The decay-corrected radiochemical yield based on [11C]CH3I was 11.9%, and the specific activity was 39.8 GBq/μmol. |
| Keywords: | PET 11C FK506 Wittig reaction |
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