Effective tuning of the arene and alkanesulfinamides for highly enantioselective synthesis of (S)-4-chlorophenylphenylmethylamine, a key intermediate for antihistamic (S)-cetirizine |
| |
Authors: | Zhengxu HanPaul Grover QKevin FangDerek A Pflum Chris H Senanayake |
| |
Institution: | Chemical Process Research and Development, Sepracor, Inc., 84 Waterford Dr., Marlborough, MA 01752, USA |
| |
Abstract: | High diastereoselectivity (>94%) has been achieved in the phenylMgBr addition process to chlorophenyl aldimine derived from the new and sterically hindered triisopropylbenzene sulfinamide (TIPBSA) in the synthesis of a key intermediate of (S)-Cetirizine. Surprisingly, under the same reaction conditions, toluenesulfinamide derived chlorophenyl aldimine provided only 10% ee. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|