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Silica sulfuric acid: an efficient and reusable catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones |
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| Authors: | Peyman SalehiMohammad Ali Zolfigol Mohammad Ali Bodaghi Fard |
| Affiliation: | a Department of Phytochemistry, Aromatic and Medicinal Plants and Drug Research Institute, Shahid Beheshti University, Evin, Tehran 1983963113, Iran b Department of Chemistry, Faculty of Science, Shahid Beheshti University, Evin, Tehran 1983963113, Iran c Department of Chemistry, Faculty of Science, Bu-Ali Sina University, Hamadan 65174, Iran |
| Abstract: | Silica sulfuric acid efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a β-dicarbonyl compound and urea or thiourea in refluxing ethanol to afford the corresponding dihydropyrimidinones in high yields. The catalyst is reusable and can be applied several times without any decrease in the yield of the reactions. |
| Keywords: | Biginelli reaction silica sulfuric acid dihydropyrimidinones catalysis solid phase |
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