Reactions of 2-bromopropanamides with conjugated bases of representative β-dicarbonyl compounds. Synthesis of 2,5-dioxopyrrolidines and oxazolidine-4-ones |
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Authors: | Paolo Marchetti |
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Affiliation: | Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 19, I-44100 Ferrara, Italy |
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Abstract: | Reactions of 2-bromopropanamides with potassium enolates of representative β-dicarbonyl compounds provide, in high yields, open and heterocyclic compounds through a CC or CO alkylation reaction. Whereas C-alkylation products form in all conditions tested under relevant diastereoselectivity, O-alkylation takes place only in the presence of silver promoters, and shows partial diastereoselectivity. |
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Keywords: | 2-bromoamides silver oxide C-alkylation O-alkylation β-dicarbonyl compounds |
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