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First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity |
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| Authors: | Pascal Sonnet Sophie Da NascimentoDanielle Marty Nicolas FranceschiniJean Guillon Jean-Daniel BrionJacques Rochette |
| Affiliation: | a G.R.B.P.D., EA 2629, 1 rue des Louvels, F-80037 Amiens Cedex 1, France b EA 2962 Pharmacochimie, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, F-33076 Bordeaux Cedex, France c Faculté de Pharmacie, Université Paris XI, Laboratoire de Chimie Thérapeutique, UMR CNRS 8076 BioCIS, 5, rue J.-B. Clément, F-92296 Châtenay-Malabry Cedex, France |
| Abstract: | The first synthesis of two segetalins B and G is described. The corresponding linear peptides were synthesized using standard automated continuous-flow SPPS methods. Ring closure positions were investigated for segetalin B. The best ring closure result was obtained between Val and Gly. |
| Keywords: | cyclopentapeptides segetalins ring-closure reaction solid-phase peptide synthesis |
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