Synthesis of pyridine fused polycyclic amines using sequential ring-closing metathesis and radical cyclisation reactions |
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| Authors: | S.Richard BakerManuel Cases Martine KeenanRichard A. Lewis Paul Tan |
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| Affiliation: | Eli Lilly & Co. Ltd, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK |
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| Abstract: | The syntheses of novel pyridine fused polycyclic bridgehead amines are described using sequential ring-closing metathesis (RCM) and 5-exo-trig intramolecular radical cyclisation reactions. Critical to the success of the two sequential steps were the RCM catalyst and/or the nature of the nitrogen atom. |
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