a Graduate School of Science and Technology, Niigata University, 2-nocho, Ikarashi, Niigata 950-2181, Japan b Faculty of Engineering, Niigata University, 2-nocho, Ikarashi, Niigata 950-2181, Japan
Abstract:
An efficient and versatile method for the stereospecific construction of α,ω-cis- and α,ω-trans-disubstituted eight- and nine-membered cyclic ethers was developed. Cyclization of the hydroxy epoxides promoted by Eu(fod)3 proceeded via an SN2 process and exo mode to provide the corresponding cyclic ethers in excellent yields.