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A convenient strategy of dimerization by microwave heating and using 2,5-diketopiperazine as scaffold |
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| Authors: | Vincenzo Santagada Ferdinando FiorinoElisa Perissutti Beatrice SeverinoSara Terracciano Giuseppe CirinoGiuseppe Caliendo |
| Affiliation: | a Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli ‘Federico II’, Via D. Montesano, 49, 80131 Naples, Italy b Dipartimento di Farmacologia Sperimentale, Università di Napoli ‘Federico II’, Via D. Montesano, 49, 80131 Naples, Italy |
| Abstract: | A novel and convenient microwave-assisted dimerization of an active peptide compound using the DKPs as scaffold is described. The key reaction giving rise to the diketopiperazine scaffold is the intermolecular coupling. No epimerization was detected in the reactions used. Conventional and microwave heating of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating. |
| Keywords: | synthesis of diketopiperazine dimerization microwave irradiation in solution |
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