Synthesis of novel simplified eleutheside analogues with potent microtubule-stabilizing activity, using ring-closing metathesis as the key-step |
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| Authors: | Raphael BeumerPau Bayó n,Piergiuliano BugadaSylvie Ducki,Nicola MongelliFederico Riccardi Sirtori,Joachim Telser,Cesare Gennari |
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| Affiliation: | a Dipartimento di Chimica Organica e Industriale, Centro di Eccellenza CISI, Universitá di Milano, Istituto CNR di Scienze e Tecnologie Molecolari, via Venezian 21, I-20133 Milano, Italy
b Pharmacia, viale Pasteur 10, I-20014 Nerviano, Italy |
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| Abstract: | The synthesis of a number of novel simplified eleutheside analogues with potent tubulin-assembling and microtubule-stabilizing properties is described, using ring-closing metathesis as the key-step for obtaining the 6-10 fused bicyclic ring system. |
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| Keywords: | allylation antitumour compounds metathesis stereocontrol |
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