The reaction of isoquinoline and dimethyl acetylenedicarboxylate with 1,2- and 1,4-benzoquinones: a novel synthesis of spiro[1,3]oxazino[2,3-a]isoquinolines |
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| Authors: | Vijay Nair AR SreekanthAT Biju Nigam P Rath |
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| Institution: | a Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum 695 019, India
b Department of Chemistry, University of Missouri, St. Louis, MI 63121-4499, USA |
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| Abstract: | The 1,4-dipolar intermediate generated by the addition of isoquinoline to dimethyl acetylenedicarboxylate is trapped by 1,2- and 1,4-benzoquinones to afford spiro1,3]oxazino2,3-a]isoquinoline derivatives in high yields. |
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