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Efficient, practical synthesis of symmetrically α,α-disubstituted α-amino acids |
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| Authors: | Trevor K EllisCollin H Martin Hisanori UekiVadim A Soloshonok |
| Institution: | Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA |
| Abstract: | Ni(II)-complex derived from glycine Schiff base with 2-N-(α-picolyl)amino]benzophenone (PABP) was found to be an ideal equivalent of nucleophilic glycine in the reactions with various alkyl halides affording an efficient, generalized and practically useful method for preparing symmetrically α,α-disubstituted α-amino acids. |
| Keywords: | α α-disubstituted α-amino acids sterically constrained amino acids equivalents of nucleophilic glycine Ni(II)-complex |
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