Palladium-catalyzed synthesis of arylacetamides from arylboronic acids |
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| Authors: | Ya-Zhen DuanMin-Zhi Deng |
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| Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, PR China |
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| Abstract: | Aryl amides were synthesized by the palladium catalyzed cross-coupling reaction of α-bromoacetamides with arylboronic acids in good yields. Both electron-donating and electron-withdrawing substituents on the aromatic ring are found to be compatible. The addition of Cu2O and PPh3 was found to be essential for good reaction yields. |
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