Fluorous electrophilic scavengers for solution-phase parallel synthesis |
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| Authors: | Wei Zhang Christine Hiu-Tung ChenTadamichi Nagashima |
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| Institution: | Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, PA 15238, USA |
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| Abstract: | A fluorous isatoic anhydride and isocyanate are synthesized and used as scavengers for amines in solution-phase parallel synthesis of urea, thiourea, and β-hydroxyamine analogs. The resulting fluorous derivatives are readily separated from the reaction mixture by solid-phase extractions (SPE) over FluoroFlash™ cartridges to give products with good purity. The SPE cartridges can be reused. |
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