A new and convergent synthesis for 2,5-diamino-tetrahydropyrimidones |
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| Authors: | Lianhong Xu Lijun ZhangClifford M Bryant Choung U Kim |
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| Institution: | Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA |
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| Abstract: | AN1057A/B has shown potent activity against MRSA. A novel and concise route to the synthesis of its heterocycle core 2,5-diamino-5,6-dihydro-1H-pyrimidine-4-one is described. This methodology allows the synthesis of an array of analogs with different amine substitutions at the 2-position. |
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