Palladium(0)-catalyzed Mizoroki-Heck reaction and Rh(I)-catalyzed asymmetric hydrogenation of polymer-supported dehydroalanine system |
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| Authors: | Takayuki DoiNobuaki Fujimoto Jun WatanabeTakashi Takahashi |
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| Institution: | Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan |
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| Abstract: | We have developed a practical route for the synthesis of peptides containing unnatural amino acids. Mizoroki-Heck reaction of polymer-supported dehydroalanine, followed by asymmetric hydrogenation was accomplished using Pd(0) and Rh(I)-DuPHOS catalysts, respectively, leading to 36 dipeptides containing phenylalanine derivatives with high stereocontrol. |
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