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Total synthesis of dehydroaltenusin |
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| Authors: | Shunya Takahashi Shinji KamisukiYoshiyuki Mizushina Kengo SakaguchiFumio Sugawara Tadashi Nakata |
| Institution: | a RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama, 351-0198, Japan b Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan c Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180, Japan |
| Abstract: | First total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described. The key step involves Suzuki-couplig reaction of aryl triflate prepared from 2,4,6-trihydroxy benzoic acid with a catechol-derived boronic acid. The synthetic sample was evaluated as a potent inhibitor against an eukaryotic DNA polymerase α. |
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