An efficient method for the conversion of aromatic and aliphatic nitriles to the corresponding N-tert-butyl amides: a modified Ritter reaction |
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Authors: | KLaxma Reddy |
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Institution: | Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA |
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Abstract: | Aromatic and aliphatic nitriles react with tert-butyl acetate in the presence of a catalytic amount of sulfuric acid to give the corresponding N-tert-butyl amides in excellent yields. |
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Keywords: | modified Ritter reaction nitriles tert-butyl acetate N-tert-butyl amides |
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