Synthesis of isogranulatimides A and B analogues possessing a 7-azaindole unit instead of an indole moiety |
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Authors: | Bernadette HugonBruno Pfeiffer Pierre RenardMichelle Prudhomme |
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Institution: | a Université Blaise Pascal, Synthèse et Etude de Systèmes à Intérêt biologique, UMR 6504 du CNRS, 63177 Aubière, France b Les Laboratoires SERVIER, 1 rue Carle Hébert, 92415 Courbevoie, France |
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Abstract: | The synthesis of a new family of isogranulatimides analogues is described in which a 7-azaindole replaces the indole moiety. The key step is the photocyclization of the aza didemnimide intermediates which leads to two isomeric analogues of isogranulatimides A and B. A derivative bearing a carbohydrate part linked to the azaindole via a β-N-glycosidic bond was also prepared. |
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Keywords: | G2 checkpoint inhibitors isogranulatimide rebeccamycin |
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