Organometallic reagent-mediated one-pot synthesis of 3,5,6-trisubstituted naphthostyrils |
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Authors: | Jin-Jun LiuFred Konzelmann Kin-Chun Luk |
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Affiliation: | Department of Discovery Chemistry, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA |
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Abstract: | A one-pot synthesis of 3,5,6-trisubstituted naphthostyrils is described. Addition of organometallic reagents to β-iodovinyl ketone 1 followed by elimination gave the Z-form β-alkyl vinyl ketone 15. Intramolecular cyclization of 15 under the reaction conditions afforded 3,5,6-trisubstituted naphthostyrils 4. |
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Keywords: | trisubstituted naphthostyril intramolecular cyclization CC bond formation organometallic reagents |
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