From terminal alkynes directly to branched amines |
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| Authors: | Ivette Garcia CastroAnnegret Tillack Christian G HartungMatthias Beller |
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| Affiliation: | Leibniz-Institut für Organische Katalyse (IfOK) an der Universität Rostock eV, Buchbinderstraße 5-6, D-18055 Rostock, Germany |
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| Abstract: | The one-pot synthesis of several branched secondary aliphatic amines is described. Hydroamination of terminal alkynes with aliphatic primary amines in the presence of Cp2Ti(η2-Me3SiCCSiMe3) gives the corresponding aldimines as intermediates. Reaction of these in situ produced aldimines with organolithium reagents (n-BuLi, PhLi) provides the α-branched amines in an easy way in upto 78% overall yield. |
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