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The biocatalytic conversion of 8-hydroxymanzamine A to manzamine A |
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| Authors: | Noer KasanahKarumanchi V. Rao Muhammad YousafDavid E. Wedge Mark T. Hamann |
| Affiliation: | a The Department of Pharmacognosy and National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA b USDA-ARS, Natural Product Utilization Research Unit, National Center for Natural Product Research, University, MS 38677, USA |
| Abstract: | The selective dehydroxylation of 8-hydroxymanzamine A (1) to form manzamine A (2) can be completed by fermentation with Fusarium solani or Streptomyces seokies. This unique biocatalytic conversion is important due to the fact that manzamine A has more desirable biological activity when assayed in a murine model against malaria. |
| Keywords: | selective dehydroxylation 8-hydroxymanzamine A Fusarium solani Streptomyces seokies |
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