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The Bohlmann-Rahtz route to functionalised pyridine scaffolds and their use in library synthesis |
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| Authors: | Katherine E. BashfordMatthew B. Burton Stuart CameronAnthony L. Cooper Rebecca D. HoggPeter D. Kane David A. MacManusChristopher A. Matrunola Christopher J. Moody Avril A.B. Robertson Mark R. Warne |
| Affiliation: | a School of Chemistry, University of Exeter, Stocker Road, Exeter EX4 4QD, UK b Tripos Receptor Research Ltd., Bude-Stratton Business Park, Bude, Cornwall EX23 8LY, UK |
| Abstract: | The Bohlmann-Rahtz reaction has been used to prepare 2,3,6-trisubstituted pyridines suitable for use in library synthesis. The synthesis of piperidine substituted nicotinic acid derivative 9 has been optimised and carried out on a large scale to give ca. 500 g of scaffold which was used in the generation of the pyridine library 11. |
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