The synthesis of β-lactams via a one-pot Reformatsky reaction of imines promoted by Zn/Cp2TiCl2 (cat.) |
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| Authors: | Lei ChenGang Zhao Yu Ding |
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| Institution: | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling lu, Shanghai 200032, PR China |
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| Abstract: | In the presence of Zn/Cp2TiCl2 (cat.) α-bromoacetates, γ-bromocrotonates or α-bromomethylacrylates react with imines in one-pot to form β-lactams, 3-vinyl-β-lactams or α-methylene-γ-lactams, respectively, at room temperature without the need for pretreatment of the solvent and Zn. |
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| Keywords: | imines azetidinones biscyclopentadienyltitanium dichloride Reformatsky reaction |
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