P-Chirogenic phosphonium salts: preparation and use in Rh-catalyzed asymmetric hydrogenation of enamides |
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Authors: | Hiroshi DanjoWataru Sasaki Takehiro MiyazakiTsuneo Imamoto |
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Affiliation: | Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan |
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Abstract: | P-Chirogenic trialkylphosphonium salts were prepared from the corresponding free phosphines by treatment with a strong acid (HBF4 or HOTf). No racemization of the phosphonium salts occurred in methanol or water even at considerably high temperature. The salts were conveniently used in rhodium-catalyzed asymmetric hydrogenation of enamides. |
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