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Convenient syntheses of (3S,5S)-carbapenam-3-carboxylates and their biosynthetic relevance |
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| Authors: | Barrie W Bycroft Siri Ram ChhabraBarrie Kellam Paul Smith |
| Affiliation: | School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK |
| Abstract: | Starting from readily available glutamate derivatives, facile stereoselective syntheses of (3S,5S)-carbapenam-3-carboxylates have been developed. Their significance in confirming the absolute configuration of the natural material is discussed. |
| Keywords: | carbapenam-3-carboxylate biosynthesis absolute configuration β-lactam tris(1,3-dihydro-2-benzoxazolin-3-yl)phosphine oxide |
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