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NMR structure elucidation of cyclic sialyl 6-sulfo Lewis x, a biologically dormant form of L-selectin ligand |
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| Authors: | Toshiyuki Hamada Hiroshi Hirota Shigeyuki Yokoyama Masanori YamaguchiNobumasa Otsubo Hideharu IshidaMakoto Kiso Akiko KanamoriReiji Kannagi |
| Affiliation: | a RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan b Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan c Department of Biophysics and Biochemistry, Graduate School of Science, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan d Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-1193, Japan e Department of Molecular Pathology, Aichi Cancer Center, Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan |
| Abstract: | The structure of cyclic sialyl 6-sulfo Lewis x, a new biologically dormant form of L-selectin ligand, was determined unambiguously by the accurate NMR analysis to have the lactamized [5.], (a), (b), [2.], (a) and (b)B conformation of its sialic acid. For the NMR structure elucidation were used various informations, such as chemical shifts values, appearance of amide proton, and NOE. |
| Keywords: | cyclic sialyl 6-sulfo Lewis x L-selectin NMR structure elucidation 5,2B boat conformation |
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