Abstract: | The methyl ester of tert-butyloxycarbonyl-β,β-dibromodehydroalanine was obtained in a one-pot procedure from bis-(N-tert-butyloxycarbonyl)dehydroalanine. The former was reacted with several boronic benzob]thiophene acids under Suzuki cross coupling conditions, to give new β,β-bis-(benzob]thienyl)dehydroalanines in high yields. These compounds were cyclized to pyrrole derivatives by treatment with Pd(OAc)2 and Cu(OAc)2 in DMF. |