Preparation of N-hydroxysuccinimido esters via palladium-catalyzed carbonylation of aryl triflates and halides |
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| Authors: | Rongliang LouMelissa VanAlstine Xufeng SunMark P. Wentland |
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| Affiliation: | Department of Chemistry, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA |
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| Abstract: | N-Hydroxysuccinimido esters of aromatic carboxylic acids (a.k.a. active esters) can be made using a potentially general, one-step procedure via Pd-catalyzed carbonylation of an aryl triflate or aryl iodide with CO and N-hydroxysuccinimide. Excellent yields (up to 94%) were observed when the reaction was done in DMSO at 70°C and 1 atmosphere of CO pressure. |
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| Keywords: | Pd-catalyzed carbonylation active ester N-hydroxysuccinimide |
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