Stereoselective synthesis of (+)-hyptolide |
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| Authors: | Juan MurgaJorge Garc?& #x a-Fortanet,Miguel Carda |
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| Affiliation: | a Depart. de Q. Inorgánica y Orgánica, Univ. Jaume I, Castellón, E-12080 Castellón, Spain
b Depart. de Q. Orgánica, Univ. de Valencia, E-46100 Burjassot, Valencia, Spain |
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| Abstract: | The first total synthesis of the naturally occurring lactone (+)-hyptolide is described. Ethyl l-lactate was the chiral starting material. Key steps of this 15-step synthesis were a Brown's asymmetric allylation, a Carreira's asymmetric ethynylation and a ring closing metathesis. |
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| Keywords: | (+)-hyptolide ring-closing metathesis asymmetric allylboration asymmetric ethynylation chiral pool |
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