Tributylmagnesium ate complex-mediated bromine-magnesium exchange of bromoquinolines: a convenient access to functionalized quinolines |
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| Authors: | Sylvain DumouchelFlorence Mongin François TrécourtGuy Quéguiner |
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| Institution: | Laboratoire de Chimie Organique Fine et Hétérocyclique, UMR 6014, IRCOF, Place E. Blondel, BP 08, 76131 Mont-Saint-Aignan Cédex, France |
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| Abstract: | 2-, 3- and 4-bromoquinolines were converted to the corresponding lithium tri(quinolyl)magnesates at −10°C by treatment with Bu3MgLi in THF or toluene. The resulting organomagnesium derivatives were quenched by various electrophiles to afford functionalized quinolines. |
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| Keywords: | quinoline Grignard reagents exchange reaction ate complexes |
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