The synthesis of 2-ketopiperazine acetic acid esters and amides from ethylenediamines with maleates and maleimides |
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| Authors: | Matthew M Abelman Karl J FisherEdward M Doerffler Paul J Edwards |
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| Institution: | a Signature BioScience, Inc., 1240 S. 47th St., Richmond, CA 94804, USA
b Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK |
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| Abstract: | The reaction of substituted ethylenediamines with various fumarates, maleates, and maleimides to form substituted ketopiperazine acetic acid esters and amides was investigated. This method affords a straightforward, high yield approach to a variety of potential peptidomimetics and can yield surprising results with regard to regio- and stereoselectivity. |
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| Keywords: | ethylenediamine dimethyl fumarate dimethyl maleate ketopiperazine |
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