Asymmetric Michael-aldol tandem cyclization of ω-oxo-α,β-unsaturated esters with 10-mercaptoisoborneol methyl ether |
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| Authors: | Katsumi NishimuraHiroshi Tsubouchi Masashi OnoTomoharu Hayama Yasuo NagaokaKiyoshi Tomioka |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan |
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| Abstract: | The asymmetric reaction of ω-oxo-α,β-unsaturated esters with lithium chiral thiolates afforded the Michael-aldol tandem cyclization products in high yield and good stereoselectivity. Reductive desulfurization gave the corresponding optically pure 2-hydroxycycloalkanecarboxylates. |
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