On the photoisomerization of the benzisothiazole portion of ziprasidone |
| |
| Authors: | Thomas R. Sharp Kyle R. LeemanD.Eugene Bryant George J. Horan |
| |
| Affiliation: | a Analytical R&D Department, Pfizer Global Research & Development, Groton, CT 06340, USA
b Chemical R&D Department, Pfizer Global Research & Development, Groton, CT 06340, USA |
| |
| Abstract: | Photostability challenge of ziprasidone in solution shows that the benzisothiazole moiety undergoes isomerization to the corresponding benzthiazole. A model compound, 3-piperazinyl-1,2-benzisothiazole, also undergoes this photoisomerization. Identification of the products has been confirmed by synthesis of the proposed molecules. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
