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Synthetic approaches to Cinchona alkaloids: the C-8/C-9 disconnection strategy |
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| Authors: | Raphaë l JankowskiDelphine Joseph,Christian Cavé Franç oise Dumas,Michè le OurevitchJacqueline Mahuteau,Georges MorgantNada Bosnjakovi? Pavlovi?,Jean d'Angelo |
| Affiliation: | a Unité de Chimie Organique, UMR CNRS 8076, Centre d'Etudes Pharmaceutiques, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France b Laboratoire de Cristallochimie Bioinorganique, Centre d'Etudes Pharmaceutiques, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France c SPMS, UMR CNRS 8580, Ecole Centrale de Paris, Grande Voie des Vignes, 92296 Châtenay-Malabry, France |
| Abstract: | When conducted in DMSO, the Hünig's base-promoted condensation of 3-quinuclidinone with quinoline-4-carboxaldehyde gave an equimolar mixture of epimeric aldols 8 with an excellent yield. |
| Keywords: | aldols alkaloids amines quinolines quinuclidines |
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