InBr3-Et3N promoted alkynylation of aldehydes and N,O-acetals under mild conditions: facile and simple preparation of propargylic alcohols and amines |
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| Authors: | Norio Sakai Maki HirasawaTakeo Konakahara |
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| Institution: | Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan |
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| Abstract: | The use of a novel InBr3-Et3N reagent system to promote addition reactions of 1-alkynes not only with a variety of aromatic or bulky aliphatic aldehydes but also with N,O-acetals is described. The corresponding propargylic alcohols or amines are produced in good to excellent yields. |
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| Keywords: | indium tribromide alkynylation propargylic alcohol propargylic amine N O-acetal |
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